HORDB

ID: hor000086
Uniprot ID: P01181
Protein name: Neurophysin 2
Gene name: AVP
Organism: Ovis aries (Sheep)
Family: Vasopressin/oxytocin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ovis (genus), Caprinae (subfamily), Bovidae (family), Pecora (infraorder), Ruminantia (suborder), Artiodactyla (order), Laurasiatheria (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
GO BP: GO:0007165 signal transduction; GO:0042310 vasoconstriction; GO:0097746 blood vessel diameter maintenance
GO CC: GO:0005576 extracellular region

Sequence: AMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEEIYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGIGFPRRV
Length: 95
Propeptide: CYFQNCPRGXXXAMSDLELRQCLPCGPGGKGRCFGPSICCGDELGCFVGTAEALRCQEEIYLPSPCQSGQKPCGSGGRCAAAGICCNDESCVTEPECREGIGFPRRVXASDRSNATLLDGPSGALLLRLVQLAAAPEPAEPAQPGVY
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor000086_AF2.pdb

hor000086_ESM.pdb

Mass:	1157119	Formula:	C407H653N123O134S15
Absent amino acids:	HW	Common amino acids:	GC
pI:	4.55	Basic residues:	9
Polar residues:	39	Hydrophobic residues:	22
Hydrophobicity:	-16.42	Boman Index:	-14198
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	56.53
Instability Index:	6070	Extinction Coefficient cystines:	2365
Absorbance 280nm:	25.16